Pyramid® + Presponse® SQ
Protect Beef and Dairy Calves from BVDV with a Modified-Live Virus Vaccine


The Pyramid® and Presponse® vaccine families protect cattle from respiratory disease by providing broad coverage against the primary viruses and bacteria that contribute to bovine respiratory disease complex.

PYRAMID + PRESPONSE SQ
1) Single-Dose, Modified-Live Virus Vaccine
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Protects against bovine viral diarrhea virus (BVDV) Type 1, including Type 1b and Type 2, infectious bovine rhinotracheitis (IBR), parainfluenza 3 (PI3), bovine respiratory syncytial virus (BRSV) and Mannheimia haemolytica.
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Provides a duration of immunity of at least 217 days against BVDV Type 1b.
2) Broad Protection
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Specifically labeled to protect against the most common type of BVDV in the country, Type 1b.
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Contains the Singer BVDV Type 1 and the 5912 BVDV Type 2 strains, which were specifically selected to offer broad antigen/antibody response.
3) Unique METASTIM Adjuvant
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Helps provide enhanced protection against key virus antigens, experienced during natural challenges and environmental stress.
4) Effective Whole-Herd Protection
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Vaccinate cows with Express® FP to prevent persistently infected calves from being born and spreading BVDV.
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Use PYRAMID 5 + PRESPONSE SQ in calves nursing pregnant cows properly vaccinated with either PYRAMID or EXPRESS FP vaccines.
PYRAMID
The PYRAMID family of modified-live virus vaccines are single-dose products providing broad coverage of bovine viral diarrhea virus (BVDV) Types 1 and 2, infectious bovine rhinotracheitis (IBR), parainfluenza 3 (PI3) and bovine respiratory syncytial virus (BRSV).
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The addition of the unique METASTIM adjuvant helps stimulate a strong immune response; METASTIM is a trusted adjuvant in many Boehringer Ingelheim vaccines that helps provide the best possible protection against key virus antigens, even in the face of natural challenges and environmental stress.
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Vaccines are available in a variety of different combinations, including five-way lepto or Lepto pomona-hardjo.
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Most products in the PYRAMID family contain the Singer BVDV Type 1 and the 5912 BVDV Type 2 strains, which were specifically selected to offer broad antigen/antibody response.
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Provides effective whole-herd protection in combination with EXPRESS FP.
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Vaccinate cows with EXPRESS FP to prevent persistently infected calves from being born and spreading the BVD virus.
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PYRAMID can be used in calves nursing cows properly vaccinated with either PYRAMID or EXPRESS FP vaccines.
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PRESPONSE SQ
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Aids in the reduction of severity of pneumonic pasteurellosis caused by Mannheimia haemolytica.
PRESPONSE HM
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Aids in the prevention of pneumonic pasteurellosis by stimulating immunity to Pasteurella multocida and aids in the reduction of respiratory disease due to Mannheimia haemolytica.

PYRAMID + PRESPONSE SQ
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2 mL administered subcutaneously
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Annual revaccination required
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See individual product labels for complete dosage information
PYRAMID
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2 mL administered subcutaneously
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Annual revaccination required
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See individual product labels for complete dosage information
PRESPONSE
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2 mL administered subcutaneously
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Healthy cattle 7 months of age or older should be vaccinated a minimum of 21 days prior to shipping or exposure to stress, which may precipitate infectious conditions
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Although only a single dose is necessary to confer active immunity, a booster dose is recommended whenever subsequent stress is likely

MSDS
Labels

PYRAMID + PRESPONSE SQ
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A small percentage of animals may show transient, mild injection-site swelling.
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Do not vaccinate within 21 days before slaughter.
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Burn container and all unused contents.
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In case of anaphylactoid reaction, administer epinephrine.
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Store in the dark at 35–45°F (2–7°C); avoid freezing.
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See individual product labels for details regarding use in pregnant cows or calves nursing pregnant cows.
PYRAMID
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A small percentage of animals may show transient, mild injection-site swelling.
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Do not vaccinate within 21 days before slaughter.
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Burn container and all unused contents.
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In case of anaphylactoid reaction, administer epinephrine.
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Store in the dark at 35–45°F (2–7°C); avoid freezing.
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See individual product labels for details regarding use in pregnant cows or calves nursing pregnant cows.
PRESPONSE
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Store in the dark at 35°–45°F (2°–7°C); do not freeze.
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Shake well; use entire contents when first opened.
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Do not vaccinate within 21 days before slaughter.
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Transient injection-site reactions may occur in a small percentage of vaccinates.
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In case of anaphylactoid reaction, administer epinephrine.
Early Vaccination for Beef Cattle Health and Performance
Dr. Peggy Thompson, DVM, Boehringer Ingelheim, shares tips on getting the most out of your respiratory vaccination program, including starting early.
BVDV Video
Watch out for the most common type of BVD virus in the country, BVDV Type 1b, and make sure your animals are protected with an approved vaccine.
Unique MetaStim® Adjuvant
PYRAMID 5 + PRESPONSE SQ includes a trusted ingredient that helps stimulate a strong immune response and provide the best possible protection.
Six Pillars of Successful Calf Raising
Get tips to avoid bovine respiratory disease and efficiently raise high-quality dairy cows.

Why Does BVDV Type 1b Matter?
John Davidson, DVM, Boehringer Ingelheim gives his top five reasons to protect against bovine viral diarrhea virus Type 1b.

BVDV Podcasts
Chris Chase, DVM, South Dakota State University, explains BVD virus, diagnosis, how it affects cattle and how to protect your animals with management and vaccines.

1Fulton RW, Ridpath JF, Saliki JT, et al. Bovine viral diarrhea virus (BVDV) 1b: predominant BVDV subtype in calves with respiratory disease. Can J Vet Res 2002;66(3):181–190.
EXPRESS®, PYRAMID® and PRESPONSE® are registered trademarks of Boehringer Ingelheim Animal Health USA Inc. All other trademarks are property of their respective owners. ©2021 Boehringer Ingelheim Animal Health USA Inc. All rights reserved. US-BOV-0411-2021