
HEARTGARD® Plus (ivermectin/pyrantel) prevents heartworm disease and treats and controls hookworms and roundworms. HEARTGARD Plus is delivered in a real-beef chew that dogs love.1
Use monthly to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of hookworms (Ancylostoma caninum, Uncinaria stenocephala and A. braziliense) and roundworms (Toxocara canis and T. leonina).

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#1 vet-recommended heartworm disease preventive2
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#1 dog-preferred heartworm disease preventive3
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Trusted, demonstrated efficacy with over 2 billion doses dispensed4
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Delicious, once-a-month real-beef chew that dogs love1
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Safe for puppies as young as 6 weeks of age (no minimum weight requirement)
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The dose of ivermectin in HEARTGARD® Plus (ivermectin/pyrantel) is essentially excreted in 72 hours5
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Treats and controls 3 species of hookworms and 2 species of roundworms
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HEARTGARD Plus offers the HEARTGARD Plus Satisfaction Guarantee

Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining Chewables to its box to protect the product from light. Because most dogs find HEARTGARD® Plus (ivermectin/pyrantel) Chewables palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
Dosage Chart
For dogs over 100 lbs, give the appropriate combination of chewables once a month.

For dogs 6 weeks of age and older.
IMPORTANT SAFETY INFORMATION: HEARTGARD® Plus (ivermectin/pyrantel) is well tolerated. All dogs should be tested for heartworm infection before starting a preventive program. Following the use of HEARTGARD Plus, digestive and neurological side effects have rarely been reported. For more information, please see full prescribing information.
- HEARTGARD® Plus (ivermectin/pyrantel) Chewables [Freedom of Information Summary; NADA 140-971]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc.; 1993.
- Data on file at Boehringer Ingelheim.
- Data on file at Boehringer Ingelheim.
- Data on file at Boehringer Ingelheim.
- Daurio CP, Cheung EN, Jeffcoat AR, Skelly BJ. Bioavailability of ivermectin administered orally to dogs. Vet Res Comm. 1992;16(2):125-130.
HEARTGARD® and the Dog & Hand logo® are registered trademarks of Boehringer Ingelheim Animal Health USA Inc.