NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) prevents canine heartworm disease, protects your canine patients from fleas and ticks, and treats and controls roundworms, and hookworms, in a delicious, beef-flavored, soft chew.
All In One Delicious Soft Chew
All In One Delicious Soft Chew
Pet owners want protection that is both convenient and effective, so we designed NexGard PLUS chews to provide effective protection in a One-And-Done monthly dose. NexGard PLUS chews are also designed to make compliance easy with a soft texture and delicious beef flavor. In a laboratory study, dogs preferred NexGard PLUS chews over SIMPARICA TRIO® (sarolaner, moxidectin, and pyrantel chewable tablets).*1 Learn more about NexGard PLUS chews by downloading the technical detailer.
*For dogs demonstrating a preference, they preferred NexGard PLUS chews over SIMPARICA TRIO
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The Science Behind NexGard PLUS Chews
The Science Behind NexGard PLUS Chews
NexGard PLUS chews are made with 3 active ingredients: afoxolaner, moxidectin, and pyrantel, to provide powerful parasite protection for your patients. With the same proven dose of afoxolaner prescribed to millions of dogs,2NexGard PLUS chews deliver an optimized dose of moxidectin that's safe and effective. Together, the 3 active ingredients provide One-And-Done monthly protection: afoxolaner kills fleas and ticks, moxidectin prevents heartworm disease, and pyrantel treats and controls roundworms and hookworms.
Educating Your Clients
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When it comes to compliance, it’s important for your clients to understand the need for parasite protection. In addition to the talking points suggested in this section, you can further educate clients with information found in the NexGard PLUS Chews Consumer Brochure linked below.
See English Brochure >
†For dogs demonstrating a preference, they preferred NexGard chews over the competition.
IMPORTANT SAFETY INFORMATION: NexGard® (afoxolaner) is for use in dogs only. The most frequently reported adverse reactions include vomiting, pruritus, lethargy, diarrhea, and lack of appetite. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for the full prescribing information.
Define the Threats
No matter where they live or what time of the year, all dogs need protection from fleas, ticks, and heartworm disease.
Lay Out the Legacy
NexGard PLUS chews are from the maker of vet-recommended NexGard®(afoxolaner), the #1 dog-preferred flea and tick chew.†3
Emphasize Compliance
With their beef flavor and soft texture, NexGard PLUS chews are designed to make monthly One-And-Done protection from fleas, ticks, heartworm disease, roundworms, and hookworms delicious for canines and easy for clients.
NexGard® Plus (afoxolaner, moxidectin, and pyrantel chewable tablets)
NexGard® Plus (afoxolaner, moxidectin, and pyrantel chewable tablets)
PRODUCT OVERVIEW
NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is indicated for the prevention of heartworm disease caused by Dirofilaria immitis, as well as the treatment and control of adult hookworm (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala) and roundworm (Toxocara canis and Toxascaris leonina) infections.
In addition, NexGard PLUS chews kill adult fleas and are indicated for the treatment and prevention of flea infestations caused by Ctenocephalides felis, and the treatment and control of Ixodes scapularis, Rhipicephalus sanguineus, Dermacentor variabilis, and Amblyomma americanum tick infestations. NexGard PLUS chews are safe to give to puppies at 8 weeks, weighing 4 pounds or more.
CLINICAL BENEFITS
Heartworm Disease Prevention: In 2 well-controlled laboratory studies, NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) was 100% effective against induced Dirofilaria immitis infections when administered for 6 consecutive months. In a well-controlled US field study consisting of 120 dogs administered NexGard PLUS chews and 124 dogs administered an active control, no dogs treated with NexGard PLUS chews tested positive for heartworm disease. All dogs treated with NexGard PLUS chews were negative for D. immitis antigen and blood microfilariae at study completion on Day 330.
Flea Treatment and Prevention: In a well-controlled laboratory study, NexGard PLUS chews demonstrated effectiveness against adult fleas. The data from previous studies using afoxolaner alone demonstrate that NexGard PLUS chews kill fleas before they can lay eggs, thus preventing subsequent flea infestations.
Tick Treatment and Control: In well-controlled laboratory studies, afoxolaner alone demonstrated effectiveness against Dermacentor variabilis, Ixodes scapularis, and Rhipicephalus sanguineus, 48 hours post-infestation, for 1 month. At 72 hours post-infestation, NexGard PLUS chews demonstrated effectiveness against Amblyomma americanum for 1 month.
Intestinal Nematode Treatment and Control: Elimination of adult roundworms (Toxocara canis and Toxascaris leonina) and hookworms (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala) was demonstrated in well-controlled laboratory studies.
DOSAGE & ADMINISTRATION
NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is given orally once a month at the minimum dosage of 1.14 mg/lb (2.5 mg/kg) afoxolaner, 5.45 mcg/lb (12 mcg/kg) moxidectin, and 2.27 mg/lb (5.0 mg/kg) pyrantel (as pamoate salt). For heartworm disease prevention, give once monthly for at least 6 months after last exposure to mosquitoes.
NexGard PLUS chews can be administered with or without food. Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a dose is missed, administer a NexGard PLUS chew and resume a monthly dosing schedule.
Heartworm Disease Prevention: NexGard PLUS chews should be administered at monthly intervals year-round, or at a minimum, administration should start within 1 month of the dog’s first seasonal exposure to mosquitoes and should continue at monthly intervals until at least 6 months after the dog’s last exposure. When replacing another monthly heartworm disease preventive product, the first dose of NexGard® PLUS should be given within a month of the last dose of the former medication.
Flea Treatment and Prevention: NexGard PLUS chews should be administered year-round at monthly intervals or started at least 1 month before fleas become active. To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea control product.
Tick Treatment and Control: NexGard PLUS chews should be administered year-round at monthly intervals or started at least 1 month before ticks become active.
Intestinal Nematode Treatment and Control: NexGard PLUS chews treat and control adult hookworms (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala) and roundworms (Toxocara canis and Toxascaris leonina). For the treatment of adult hookworm and roundworm infections, NexGard PLUS chews should be administered as a single dose. Monthly use of NexGard PLUS chews will control any subsequent infections. Dogs may be exposed to and can become infected with hookworms and roundworms throughout the year, regardless of season or climate.
SAFETY
IMPORTANT SAFETY INFORMATION: NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is for use in dogs only. The most frequently reported adverse reactions reported in clinical trials were diarrhea, vomiting, lethargy, and itching. NexGard PLUS contains afoxolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of seizures. Use with caution in dogs with a history of seizures or neurological disorders. The safe use of NexGard PLUS has not been evaluated in breeding, pregnant, or lactating dogs. Dogs should be tested for existing heartworm infection prior to starting a heartworm disease preventive. For heartworm disease prevention, give once monthly for at least 6 months after last exposure to mosquitoes.
For more information, click here for full prescribing information.
6 Months Protection, Save $35‡
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NexGard PLUS Rebate
Get your clients a $35 rebate when they purchase 6 doses of NexGard PLUS chews from your clinic.
‡Available only on purchases from your veterinarian. One coupon required for every 6 doses purchased. May not be combined with any other offer for NexGard PLUS chews. Rebate in the form of a NexGard PLUS Chews Mastercard® Prepaid Card.
Rebates & Education
All Pet Owner Rebates
Studies
Links to Studies
- Efficacy of moxidectin, using various dose regimens, against JYD-34, a macrocyclic lactone resistant isolate of Dirofilaria immitis
- Safety of an oral combination of moxidectin, afoxolaner, and pyrantel pamoate in dogs
- Efficacy of an oral combination of moxidectin, afoxolaner, and pyrantel pamoate for the prevention of heartworm disease in dogs
Support Websites
Web Resources for Your Clinic
Canine Parasiticides
From heartworm disease prevention, intestinal parasite treatment and control, to flea and tick protection, our products continue to be options for every pet.
References
1. Data on file at Boehringer Ingelheim.
2. Data on file at Boehringer Ingelheim.
3. Data on file at Boehringer Ingelheim.
Trademarks
NexGard® is a registered trademark of Boehringer Ingelheim Animal Health France, used under license. BI-CONNECT™ is a trademark of Boehringer Ingelheim Animal Health USA Inc. All other trademarks are the property of their respective owner. ©2023 Boehringer Ingelheim Animal Health USA Inc., Duluth, GA. All rights reserved.
US-PET-0178-2023-V2