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ANTIVENIN (Crotalidae) Polyvalent


ANTIVENIN (Crotalidae) Polyvalent is indicated for use in dogs which have received bites from viperene snakes, such as rattlesnakes, copperheads, and cottonmouth water moccasins.1


Snakebites are a painful, life-threatening medical emergency, and can even lead to permanent damage.2 After a snakebite, fast, effective action is the key to survival. Don’t be caught without ANTIVENIN (Crotalidae) Polyvalent for dogs!


ANTIVENIN is a refined and concentrated preparation of equine serum globulins obtained from healthy horses immunized with venom from 4 different species of pit vipers. ANTIVENIN helps improve care for your patients by neutralizing venom and reducing pain. ANTIVENIN neutralizes the venom of viperene snakes, including all North American species of:* 

  • Rattlesnakes

  • Copperheads

  • Cottonmouth moccasins


ANTIVENIN is a proven safe and efficacious line of treatment for canine snakebites.

In a field study, practicing veterinarians noted:1

  • Uniformly successful results with canine patients experiencing mild symptoms at the time of treatment

  • 82% overall survival rate compared to untreated, where the majority did not survive

  • 90% survival rate when administered within 4 hours of the bite 


*ANTIVENIN is not effective against Elapidae species (such as coral snakes) and is moderately effective against Mohave rattlesnakes.



The dose varies from 10 to 50 mL (1 to 5 vials), intravenously, of rehydrated ANTIVENIN (Crotalidae) Polyvalent, depending on the severity of symptoms, lapse of time after the bite, size of snake and size of patient (the smaller the body of the victim, the larger the dose required). Additional doses should be given every 2 hours as required, if symptoms such as swelling and pain persist or recur. 


In emergency, when exposure is such that intravenous administration of ANTIVENIN is not practical, the product may be administered intramuscularly as close to the site of exposure as practical.


General supportive therapy should be instituted whenever required. The use of corticosteroids is controversial. Use professional discretion.


Attempts should be made to immobilize the patient until treatment is initiated. The use of excessive heat or cold is contraindicated. Use antihistamines, tranquilizers, sedatives, and analgesics with care because they may mask important clinical signs. Use professional discretion. 


Storage temperature not to exceed 98°F (37°C). Avoid freezing and excessive heat. Use immediately after rehydration. In case of anaphylactoid reaction, administer epinephrine. Restricted to use by or on the order of a licensed veterinarian.

  1. ANTIVENIN (Crotalidae) Polyvalent [prescribing information]. St. Joseph, MO: Boehringer Ingelheim Vetmedica, Inc.; 2011.
  2. Brant-Gwaltney S. Overview of Snakebite. Merck Veterinary Manual website. Accessed October 10, 2019.

ANTIVENIN (Crotalidae) Polyvalent does not stimulate active immunity to protect dogs from venomous snakebites. It is a refined preparation of equine serum globulins used to treat dogs after snakebite. For more information, please see full prescribing information