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IMMITICIDE®(melarsomine dihydrochloride) Sterile Powder

INDICATIONS

IMMITICIDE® (melarsomine dihydrochloride) Sterile Powder is indicated for the treatment of stabilized Class 1, 2 and 3 heartworm disease caused by immature to mature adult infections of Dirofilaria immitis in dogs.

 

CONTRAINDICATIONS: IMMITICIDE is contraindicated in dogs with very severe (Class 4) heartworm disease. Patients in this category have Caval Syndrome (D. immitis present in the venae cavae and right atrium).

CLINICAL BENEFITS

  • Melarsomine dihydrochloride, the active ingredient in IMMITICIDE® (melarsomine dihydrochloride) Sterile Powder, is the only AHS-recommended treatment for canine heartworm disease1

  • Backed by scientific studies, IMMITICIDE has been approved and produced by a trusted company for over 25 years

  • Two dosing protocols, based on disease severity

  • Over 4 million doses sold2

DOSAGE & ADMINISTRATION

IMMITICIDE® (melarsomine dihydrochloride) Sterile Powder should be administered ONLY by deep intramuscular injection in the epaxial (lumbar) muscles in the third through fifth lumbar region. DO NOT ADMINISTER AT ANY OTHER SITE. Avoid superficial injection or leakage.

 

Use a 23 gauge 1 inch needle for dogs equal to or less than 22 lbs (10 kg) in weight. Use a 22 gauge 1 ½ inch needle for dogs greater than 22 lbs (10 kg).

 

Use alternating sides with each administration. If repeated administrations are warranted, avoid injecting at the same lumbar location. Record the location of the first injection(s) in the patient's medical record for future reference.

 

Care must be taken to administer the proper dose. Accurately weigh the dog and calculate the volume to be injected based on the dose of 2.5 mg/kg (1.1 mg/lb). This is equivalent to 0.1 mL/kg (0.045 mL/lb).

 

It is vital to classify the severity of heartworm disease to apply the appropriate dosage regime for IMMITICIDE. IMMITICIDE should not be used in dogs with very severe (Class 4) heartworm disease. For complete dosing information according to heartworm disease class, please refer to the full prescribing information.

SAFETY

IMMITICIDE® (melarsomine dihydrochloride) Sterile Powder has a low margin of safety. Adverse reactions, primarily at the injection sites, were seen at the recommended dose in clinical trials.

 

HUMAN WARNINGS: Keep this and all medications out of the reach of children. Avoid human exposure. Wash hands thoroughly after use or wear gloves. Potentially irritating to eyes. Rinse eyes with copious amounts of water if exposed. Consult a physician in cases of accidental exposure by any route (dermal, oral, or by injection).

 

IMPORTANT SAFETY INFORMATION: IMMITICIDE Sterile Powder should not be used in dogs with very severe (Class 4) heartworm disease. IMMITICIDE should be administered by deep intramuscular injection in the lumbar (epaxial) muscles (L3–L5) only. Do not use in any other muscle group. Do not use intravenously. Care should be taken to avoid superficial injection or leakage. Serious adverse reactions may occur in any dog with heartworm disease due to the killing of heartworms in the pulmonary arteries. Reactions may include thromboembolism, dyspnea, coughing, depression, right side heart failure and death. Dogs should be cage rested following treatment due to possible  thromboembolic disease. Post-injection site reactions (e.g. pain, swelling) were the most commonly reported adverse events. See full Prescribing Information for dosing and administration directions prior to each use of IMMITICIDE. For more information, please see full prescribing information

References
  1. American Heartworm Society. Summary of the current canine guidelines for the prevention, diagnosis, and management of heartworm (Dirofilaria immitis) infection in dogs. https://www.heartwormsociety.org/images/pdf/Canine-Guidelines-Summary.pdf. Accessed August 11, 2020.
  2. Data on file at Boehringer Ingelheim.
Trademarks

IMMITICIDE® is a registered trademark of the Boehringer Ingelheim Group.

US-PET-0563-2020
IMPORTANT SAFETY INFORMATION

IMMITICIDE® (melarsomine dihydrochloride) Sterile Powder should not be used in dogs with very severe (Class 4) heartworm disease. IMMITICIDE should be administered by deep intramuscular injection in the lumbar (epaxial) muscles (L3–L5) only. Do not use in any other muscle group. Do not use intravenously. Care should be taken to avoid superficial injection or leakage. Serious adverse reactions may occur in any dog with heartworm disease due to the killing of heartworms in the pulmonary arteries. Reactions may include thromboembolism, dyspnea, coughing, depression, right side heart failure, and death. Dogs should be cage rested following treatment due to possible thromboembolic disease. Post-injection site reactions (eg, pain, swelling) were the most commonly reported adverse events. See full Prescribing Information for dosing and administration directions prior to each use of IMMITICIDE. For more information, see full prescribing information.