Species
A golden retriever sits with a soccer ball
A golden retriever sits with a soccer ball

RECOMBITEK® Canine Vaccines

Safe and effective, the entire family of RECOMBITEK® vaccines help provide proven protection for dogs and puppies.

A vet holds a dog's face in her hands

An Integrated Approach

When veterinarians asked for a combination vaccine for core antigens and against leptospirosis, Boehringer Ingelheim developed RECOMBITEK® C8, the only vaccine containing a canarypox-vectored recombinant distemper, and a nonadjuvanted leptospirosis vaccine with a 15-month duration of immunity against Leptospira grippotyphosa.1,2

 

Historically, canine Lyme disease vaccines have been known to cause increased vaccine reactions, likely resulting from the numerous proteins.3 When asked for a solution to this problem, we created RECOMBITEK® Lyme, the first and only nonadjuvanted canine Lyme disease vaccine created with just a single protein, outer surface protein A (OspA), for pure, targeted protection.4

 

We listen. We innovate. We solve. That’s how Boehringer Ingelheim gives you the power to help protect your patients from dangerous and deadly diseases while helping you deepen the emotional bond they share with their owners.

An Integrated Approach

When veterinarians asked for a combination vaccine for core antigens and against leptospirosis, Boehringer Ingelheim developed RECOMBITEK® C8, the only vaccine containing a canarypox-vectored recombinant distemper, and a nonadjuvanted leptospirosis vaccine with a 15-month duration of immunity against Leptospira grippotyphosa.1,2

 

Historically, canine Lyme disease vaccines have been known to cause increased vaccine reactions, likely resulting from the numerous proteins.3 When asked for a solution to this problem, we created RECOMBITEK® Lyme, the first and only nonadjuvanted canine Lyme disease vaccine created with just a single protein, outer surface protein A (OspA), for pure, targeted protection.4

 

We listen. We innovate. We solve. That’s how Boehringer Ingelheim gives you the power to help protect your patients from dangerous and deadly diseases while helping you deepen the emotional bond they share with their owners.

A vet holds a dog's face in her hands

Lifestyle Vaccines

Recommended for dogs based on lifestyle, geographic location, and risk of exposure.5

Order Now

Log in to your BI-CONNECT™ account or create a new account to place an order.

Log In or Sign Up

‏

Bottle of Recombitek Oral Bordetella

RECOMBITEK® Oral Bordetella

Bordetella bronchiseptica

Learn More

‏

Bottle of RECOMBITEK® 4 Lepto (LCGIP)

RECOMBITEK® 4 Lepto (LCGIP)

Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona

Learn More

‏

Bottle of RECOMBITEK® Lyme (rLyme)

RECOMBITEK® Lyme (rLyme)

Borrelia burgdorferi Bacterial Extract

Learn More

‏

Bottle of RECOMBITEK® KC2

RECOMBITEK® KC2

Canine Parainfluenza-Bordetella bronchiseptica

Core Vaccines

Recommended for all dogs regardless of lifestyle, unless there is a specific medical reason not to vaccinate.5

‏

Bottle of RECOMBITEK® Canine Parvo (CPV)

RECOMBITEK® Canine Parvo (CPV)

Canine Parvovirus

Learn More

‏

Bottle of RECOMBITEK® C3 (rDAP)

RECOMBITEK® C3 (rDAP)

Canine Distemper-Adenovirus Type 2-Parvovirus

‏

Bottle of RECOMBITEK® C4 (rDAPP)

RECOMBITEK® C4 (rDAPP)

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus

‏

Bottle of RECOMBITEK® C4/CV (rDAPPC)

RECOMBITEK® C4/CV (rDAPPC)

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus-Coronavirus

‏

Bottle of RECOMBITEK® C7 (rDAP-LCGIP)

RECOMBITEK® C7 (rDAP-LCGIP)

Canine Distemper-Adenovirus Type 2-Parvovirus 
Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona

‏

Bottle of RECOMBITEK® C8 (rDAPP-LCGIP)

RECOMBITEK® C8 (rDAPP-LCGIP)

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus 
Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona

Diagram of a Canine Distemper Virus

Why Recombinant Technology?

The use of recombinant proteins in some of our canine vaccines allows the targeting of immune responses against a few protective antigens.6 
This allows vaccines to be developed that contain only the necessary immunogenic protein(s) rather than the entire virus or bacteria.

Why Recombinant Technology?

The use of recombinant proteins in some of our canine vaccines allows the targeting of immune responses against a few protective antigens.6 
This allows vaccines to be developed that contain only the necessary immunogenic protein(s) rather than the entire virus or bacteria.

Diagram of a Canine Distemper Virus
An illustration showing three vials for killed vaccines, modified-live virus vaccines, and recombinant vaccines

Different Vaccine Types

There are 3 types of vaccines that are available commercially for dogs and cats: killed (inactivated) vaccines, modified-live virus (MLV) vaccines, and recombinant vaccines.

  • A killed vaccine uses an inactivated (killed) bacteria or virus. Killed vaccines frequently include additional compounds, called adjuvants, intended to help increase the overall effectiveness of the vaccine.7
  • A modified-live virus (MLV) vaccine is a weakened (or attenuated) version of the disease-causing virus. These vaccines stimulate an immune response similar to the response generated through natural infection.
  • Recombinant vaccines contain only the necessary immunogenic protein(s) rather than the entire virus or bacteria. They are developed by selecting individual proteins that are present in that particular virus or bacteria when administered to the patient, only 1 or 2 types of antibodies are created, resulting in a targeted, effective immune response.

Different Vaccine Types

There are 3 types of vaccines that are available commercially for dogs and cats: killed (inactivated) vaccines, modified-live virus (MLV) vaccines, and recombinant vaccines.

  • A killed vaccine uses an inactivated (killed) bacteria or virus. Killed vaccines frequently include additional compounds, called adjuvants, intended to help increase the overall effectiveness of the vaccine.7
  • A modified-live virus (MLV) vaccine is a weakened (or attenuated) version of the disease-causing virus. These vaccines stimulate an immune response similar to the response generated through natural infection.
  • Recombinant vaccines contain only the necessary immunogenic protein(s) rather than the entire virus or bacteria. They are developed by selecting individual proteins that are present in that particular virus or bacteria when administered to the patient, only 1 or 2 types of antibodies are created, resulting in a targeted, effective immune response.
An illustration showing three vials for killed vaccines, modified-live virus vaccines, and recombinant vaccines

Satisfaction Guarantee

Our commitment starts with science and technology to help you protect your patients and continues with support for you and your clients. To this end, we provide support in the event of a suspected adverse event (AE) or perceived lack of efficacy (LOE) associated with our vaccines and will provide reimbursement for any unused, expired doses, even if the vaccine tray has been opened.

Learn More

‏

Bottles of Recombitek Vaccines

RECOMBITEK® Canine Vaccines

 

RECOMBITEK® vaccines are highly purified, making them a safe and effective option to help protect your canine patients from dangerous diseases.

 

Learn More
Bottles of Recombitek Vaccines

RECOMBITEK® Canine Vaccines

 

RECOMBITEK® vaccines are highly purified, making them a safe and effective option to help protect your canine patients from dangerous diseases.

 

Learn More
Bottles of IMRAB Vaccines

IMRAB® Rabies Vaccines

 

Veterinarians worldwide trust US market-leading IMRAB® vaccines for proven multi-species rabies protection.8

 

Learn More
Bottles of IMRAB Vaccines

IMRAB® Rabies Vaccines

 

Veterinarians worldwide trust US market-leading IMRAB® vaccines for proven multi-species rabies protection.8

 

Learn More
Bottles of PUREVAX vaccines

PUREVAX® Feline Vaccines

 

Adjuvants can present potential risks to feline patients.9,10,11 PUREVAX® feline vaccines have been designed to elicit a protective immune response without the addition of adjuvants.

 

Learn More
Bottles of PUREVAX vaccines

PUREVAX® Feline Vaccines

 

Adjuvants can present potential risks to feline patients.9,10,11 PUREVAX® feline vaccines have been designed to elicit a protective immune response without the addition of adjuvants.

 

Learn More
Bottles of Recombitek Vaccines

RECOMBITEK® Canine Vaccines

 

RECOMBITEK® vaccines are highly purified, making them a safe and effective option to help protect your canine patients from dangerous diseases.

 

Learn More
Bottles of Recombitek Vaccines

RECOMBITEK® Canine Vaccines

 

RECOMBITEK® vaccines are highly purified, making them a safe and effective option to help protect your canine patients from dangerous diseases.

 

Learn More
Bottles of IMRAB Vaccines

IMRAB® Rabies Vaccines

 

Veterinarians worldwide trust US market-leading IMRAB® vaccines for proven multi-species rabies protection.8

 

Learn More
Bottles of IMRAB Vaccines

IMRAB® Rabies Vaccines

 

Veterinarians worldwide trust US market-leading IMRAB® vaccines for proven multi-species rabies protection.8

 

Learn More
Bottles of PUREVAX vaccines

PUREVAX® Feline Vaccines

 

Adjuvants can present potential risks to feline patients.9,10,11 PUREVAX® feline vaccines have been designed to elicit a protective immune response without the addition of adjuvants.

 

Learn More
Bottles of PUREVAX vaccines

PUREVAX® Feline Vaccines

 

Adjuvants can present potential risks to feline patients.9,10,11 PUREVAX® feline vaccines have been designed to elicit a protective immune response without the addition of adjuvants.

 

Learn More

References

  1. RECOMBITEK® 4 Lepto Product Label.

  2. Grosenbaugh DA, Pardo MC. Fifteen-month duration of immunity for the serovar grippotyphosa fraction of a tetravalent canine leptospirosis vaccine. Vet Record. 2018;182(23):665-665.

  3. Moore GE, Guptill LF, Ward MP, et al. Adverse events diagnosed within three days of vaccine administration in dogs. J Am Vet Med Assoc. 2005;227(7):1102-1108.

  4. RECOMBITEK® Lyme Product Label.

  5. Ellis J, Marziani E, Aziz C, et al. 2022 AAHA Canine Vaccination Guidelines. J Am Anim Hosp Assoc. 2022; 58:1-19.

  6. Nascimento IP, Leite LCC. Recombinant vaccines and the development of new vaccine strategies. Braz J Med Biol Res. 2012;45:1102-1111.

  7. Tizard I. Types of vaccines for animals - pharmacology. Merck Veterinary Manual. Accessed November 23, 2022. https://www.merckvetmanual.com/pharmacology/vaccines-and-immunotherapy/types-of-vaccines-for-animals

  8. Data on file at Boehringer Ingelheim.

  9. Greene CE, Schultz RD. Immunoprophylaxis. In: Greene CE, ed. Infectious Diseases of the Dog and Cat. 4th ed. St Louis, MO: Elsevier Saunders; 2012:1166-1169.

  10. McNeil MM, DeStefano F. Vaccine-associated hypersensitivity. J Allergy Clin Immunol. 2018;141(2):463-472.

  11. Day MJ, Schoon H-A, Magnol J-P, et al. A kinetic study of histopathological changes in the subcutis of cats injected with non-adjuvanted and adjuvanted multi-component vaccines. Vaccine. 2007; 25:4073-4084.

Trademarks

RECOMBITEK® and IMRAB® are registered trademarks and BI-CONNECT™ is a trademark of Boehringer Ingelheim Animal Health USA Inc. PUREVAX® is a registered trademark of Boehringer Ingelheim Animal Health France, used under license. ©2023 Boehringer Ingelheim Animal Health USA Inc., Duluth, GA. All rights reserved. 

US-PET-0234-2021-A-V2