Species

PREVEXXION® RN & VAXXITEK® 
HVT+IBD

A Combination That Is Hard To Crack

 

 

Details

These two vaccines in one injection, a vectored vaccine and a chimera, provide added protection for improved Marek’s disease virus (MD) and infectious bursal disease (IBD) coverage. This vaccination solution provides protection against virulent and very virulent strains of MD plus variant and classic strains of IBD for your flock including broilers, breeders, and other long-lived birds, achieving the right combination for MD which remains the major challenge for sustainable control of this disease worldwide. 
 

PREVEXXION® RN was efficacious when used in combination with a vectored vaccine such as VAXXITEK® HVT+IBD1,2  
 
The protection is high against Marek’s disease RB1B challenge at four days-of-age1,2  
 
PPEVEXXION® RN 
*Innovative attenuation process delivers the right balance between safety3 & efficacy3 
 
VAXXITEK® HVT+IBD 

  • VAXXITEK® HVT+IBD is an HVT-based vector vaccine 

  • Contains the viral VP2 protein to stimulate IBD immunity 

  • Systemic replication of the vector induces protection against 2 important diseases 

 

Key Advantages 

  • One hatchery administration to protect against IBD and MD at day old-or in ovo 

  • Reduces the risk of vaccine confusion 

  • Onset of immunity from four days of age4 

  • Long-lasting immunity5 like classic serotype 1 vaccines even for long-lived birds  

  • Protection against the most virulent MD virus  

  • Improved bursal health 

  • Delivers the right safety6 and efficacy7 balance  

  • Efficacious for chickens vaccinated in ovo8  

  • Broad spectrum protection against most pathotypes of the IBD virus 

  • Controlling immunosuppression will reduce the need for antibiotics6  

 

PREVEXXION(R)-VAXXITEK HVT+IBD
Features & Benefits

Prevexxion® RN

  • Unprecedented and controlled attenuation process for Marek’s disease strain that results from different MD virus and LTR gene sequence insertions 

  • Same convenient application as classic Marek’s disease vaccines 

  • No reversion to virulence9 

 

VAXXITEK® HVT+IBD

  • No interference with maternal antibodies6  

  • Excellent primer and is effective in all types of poultry businesses – broiler, layer, and breeder chickens 

  • HVT and VP2 will induce immune responses that protect against IBD and MD10  

  • VP2 elicits neutralizing antibodies 

  • More than 70 scientific papers published to date11 

  • 100 billion birds vaccinated since first launch in 200612 

Dosage & Administration

Packaged in 5 x 2000 dose ampules in frozen presentation

Resources

One Pager

PREVEXXION VAXXITEK

 

 

US-POU-0008-2021

 

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Safety

  • Do not mix with other products, except as specified on the label 

  • In case of human exposure, contact a physician  

  • Use entire contents when first opened 

  • Do not vaccinate within 21 days before slaughter 

  • Do not vaccinate diseased embryonated eggs or birds 

  • Administer a full dose to each embryonated egg or to each bird 

  • Vaccinate all birds on the premises at one time 

  • Avoid stress conditions during and following vaccination 

  • Do not place chickens in contaminated facilities 

  • Exposure to disease must be minimized as much as possible 

  • Contains penicillin and streptomycin sulfate which are added as bacteriostatic agents 

  • Contains Amphotericin B as a fungistatic agent 

  • Inactivate unused contents before disposal 

 

 

Safety Data Sheet

PREVEXXION RN & VAXXITEK HVT+IBD
References

1Data on file at Boehringer Ingelheim.

2Data on file at Boehringer Ingelheim.

3Morrow C., Fehler F. 2004, Marek’s disease: A worldwide problem, p49-61 in Davison, F, Nair V. Elsevier, London, United Kingdom.

4Data on file at Boehringer Ingelheim.

5Data on file at Boehringer Ingelheim.

6Bublot M, Pritchard N, Le Gros F-X, Goutebroze S. Use of vectored vaccine against infectious bursal disease of chickens in the face of high-titered maternal derived antibody. Journal of Comparative Pathology, 2007; 137:81-84.

7Garritty AT. The effect of vectored HVT+IBD (Vaxxitek® HVT+IBD) vaccination on body weights, uniformity and virus shedding in commercial broilers. Abstract. International Poultry Scientific Forum, Atlanta, 2011; p31.

8Lemiere S, Rojo R, He S, Tang S, Li Wi, Herrmann A, Prandini F. Benefits of the Herpesvirus of Turkey vector vaccine of IBD in control of immune depression in broilers and decrease of use of antibiotic medication. Abstract XVIII, World Veterinary Association Congress.

9Witter R.L. & al., Induction of Strong Protection by Vaccination with Partially Attenuated Serotype 1 Marek’s Disease Viruses, 2002 Avian Diseases, 46(4):925-937.

10Bublot M. Vector vaccines for poultry: their advantages and limitations compared to classical vaccines. Proceedings of the International Symposium on Poultry Diseases, 14-15, December 2015.

11Data on file at Boehringer Ingelheim.

12Data on file at Boehringer Ingelheim.

Trademarks

PREVEXXION® and VAXXITEK® are registered trademarks of Boehringer Ingelheim Animal Health USA Inc. ©2023 Boehringer Ingelheim Animal Health USA Inc., Duluth, GA. All Rights Reserved. US-POU-0063-2022