INGELVAC CIRCOFLEX with DiaTEC

 

For more than 10 years, producers have depended on INGELVAC CIRCOFLEX for protection against porcine circovirus Type 2 (PCV2), either in its monovalent form or as part of FLEXcombo^® and 3FLEX^®. 

As a partner in swine health, Boehringer Ingelheim is always striving for innovative solutions that help producers better protect their herds from disease. To that end, thanks to a state-of-the-art purification process called DiaTEC, INGELVAC CIRCOFLEX is non-virucidal,¹ greatly enhancing the versatility of the vaccine when used as part of 3FLEX, while maintaining the high level of disease protection producers and veterinarians have come to expect from the product.

Boehringer Ingelheim’s DiaTEC process is a unique diafiltration process that is part of the overall INGELVAC CIRCOFLEX manufacturing process.

DiaTEC removes residual cell media components from the antigens, or virus-like particles (VLPs), in the vaccine, resulting in a non-virucidal vaccine that provides producers and veterinarians with the following benefits:

Greater versatility

 

When using 3FLEX, producers and veterinarians can mix the three vaccine components in any order. It is no longer necessary to adhere to the specific “1-2-3” mixing order, because INGELVAC CIRCOFLEX is no longer virucidal to the modified-live Ingelvac PRRS^® MLV component. This enhancement provides producers and veterinarians with greater versatility.

State-of-the-art purification process

 

DiaTEC removes residual baculovirus proteins and cell debris from the VLPs without affecting the antigen load, resulting in a highly immunogenic and non-virucidal vaccine that’s clear in color.

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The same strong, safe immune response

 

• The non-virucidal INGELVAC CIRCOFLEX maintains the proven efficacy and safety producers and veterinarians have come to expect from the vaccine.
• The vaccine dosage, administration method and timing, as well as duration and onset of immunity, are unchanged.
• INGELVAC CIRCOFLEX still includes ImpranFLEX^®, a proprietary water-based polymer adjuvant that works with VLPs to prolong the release of antigens, so the concentrated formulation can provide fast, long-lasting disease protection in one dose.

Boehringer Ingelheim is dedicated to research and development, and is committed to being a partner in swine health with our customers. For this reason, and because we understand the global challenges facing the swine industry, this enhancement to INGELVAC CIRCOFLEX will not impact the price of the vaccine.

For more information, learn more about INGELVAC CIRCOFLEX or talk to your Boehringer Ingelheim representative.

 

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References

¹ Bautista E, Schlesinger K, Gassel M. Boehringer Ingelheim Animal Health USA Inc. Data on file, Study No. 2017044.

 

3FLEX^®, FLEXCOMBO^®, INGELVAC PRRS^®, INGELVAC CIRCOFLEX^® and IMPRANFLEX^® are registered trademarks of Boehringer Ingelheim Vetmedica GmbH, used under license. ©2022 Boehringer Ingelheim Animal Health USA Inc., Duluth, GA. All Rights Reserved. US-POR-0162-2022