Having first been identified in 2012, today porcine Circovirus Type 2d (PCV2d) is the predominant genotype circulating in the United States, accounting for more than 90% of PCV2 infections.^1-2

An extensive body of research has demonstrated that Ingelvac CircoFLEX^®, a PCV2a-based vaccine, can provide heterologous cross-protection against PCV2d.^3-7 In most cases, producers can rely on this trusted vaccine to protect their herds from the harmful effects of porcine circovirus associated disease (PCVAD). But in some scenarios, such as a PCV2d infection along with severe co-infections, prevention of PCV2d’s clinical impact calls for a different approach.

That’s why Boehringer Ingelheim introduced d-FENSE, the swine industry’s first PCV2d-based killed baculovirus vector vaccine. It is designed to provide a different approach for extreme PCVAD presentations.

• Onset of immunity within two weeks of vaccination. 
• Single-dose (1 mL) PCV2 vaccine.  
• Can be administered to pigs 3 weeks of age and older. 
• Provides a duration of immunity of at least four months. 
• Low risk of adverse reactions and stress on pigs due to one-dose administration. 
• PQA^® Plus friendly. 
• Contains ImpranFLEX^®, an effective, aqueous-based (non-oil) polymer adjuvant. 
• Flexible vaccination scheduling. 
• Reduces PCV2 viremia. 

Shake well before use. Using aseptic technique, administer a single 1-mL dose by intramuscular injection. 

d-FENSE Safety Data Sheet (SDS)

Uses

• For vaccination of healthy, susceptible pigs 3 weeks of age or older as an aid in the prevention of lymphoid depletion, inflammation and colonization of lymphoid tissue. 
• As an aid in reduction of the magnitude of viremia associated with porcine circovirus Type 2 (PCV2d).  

Precautions

• Store out of direct sunlight at 35° – 46°F (2° – 8°C). Do not freeze. Use entire contents when first opened.
• Do not vaccinate within 21 days before slaughter.
• In case of anaphylactic reaction, epinephrine is symptomatic treatment.
• This product has not been tested in pregnant animals.
• In case of human exposure, contact a physician.